April 19, 2012
Bacteria associated with gum disease may relocate to the joints and cause hip or knee prosthesis failure, according to researchers from Case Western Reserve University School of Dental Medicine…
…The researchers suggest the findings may explain why aseptic loosening or prosthetic wear of artificial joints occurs within 10 years when no infection appears to be present. The findings were reported in the Journal of Clinical Rheumatology…
…Bacterial DNA was collected from the synovial fluid of hip and knee joints. The researchers also gathered pooled subgingival samples and examined the patients for periodontal disease. The investigators found bacterial DNA in the synovial fluid of 13.9% of patients – two RA patients (one native knee, one failed prosthesis) and three OA patients (one native knee, two failed prostheses).
"We have a link now and want to see just how much of a trend this is," Bissada stated. "We also will be able to see if treating the periodontal disease can reduce the future of costly joint replacements."
Témoin S, Chakaki A, Askari A, et al. Identification of oral bacterial DNA in synovial fluid of patients with arthritis with native and failed prosthetic joints. J Clin Rheumatol. 2012; 18(3):117-121. doi: 10.1097/RHU.0b013e3182500c95.